Hot off the presses! Jun 01 Nat Rev

The Jun 01 issue of the Nat Rev is now up on Pubget (About Nat Rev): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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  - Nat Rev 12(6):341 (2011)
  
• Cell cycle: Building the centriole | PDF (431 KB)
  - Nat Rev 12(6):342 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Cell growth: RAC1 sizes up mTOR | PDF (210 KB)
  - Nat Rev 12(6):343 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• The three SMC sisters | PDF (145 KB)
  - Nat Rev 12(6):343 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Autophagy: Shaping the fate of mitochondria | PDF (274 KB)
  - Nat Rev 12(6):344 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Gene expression: Personalized ribosomes | PDF (319 KB)
  - Nat Rev 12(6):344 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Technique | Stem cells | Development | PDF (105 KB)
  - Nat Rev 12(6):344 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Metabolism: Fight the fat, cure the (ER) stress | PDF (168 KB)
  - Nat Rev 12(6):345 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• A fat-burning solution | PDF (116 KB)
  - Nat Rev 12(6):346 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• DNA damage: Problems with too much packaging | PDF (226 KB)
  - Nat Rev 12(6):346 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Cytoskeleton: RhoC invades cofilin's space | PDF (163 KB)
  - Nat Rev 12(6):346 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Signalling | Nuclear organization | Gene expression | PDF (103 KB)
  - Nat Rev 12(6):347 (2011)
  Phosphatases are known to play many regulatory parts during the cell cycle. Two groups now show for the first time that, in Caenorhabditis elegans, the phosphatase PP2A has a key role in centriole assembly, a process that is crucial for proper cell division.
• Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
  - Nat Rev 12(6):349 (2011)
  Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development — by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres — have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.
• ARF family G proteins and their regulators: roles in membrane transport, development and disease
  - Nat Rev 12(6):362 (2011)
  Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development — by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres — have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.
• Keeping mRNPs in check during assembly and nuclear export
  - Nat Rev 12(6):377 (2011)
  Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development — by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres — have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.
• Mitotic catastrophe: a mechanism for avoiding genomic instability
  - Nat Rev 12(6):385 (2011)
  Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development — by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres — have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.
• Turing's next steps: the mechanochemical basis of morphogenesis
  - Nat Rev 12(6):400 (2011)
  Skeletal muscle is the dominant organ system in locomotion and energy metabolism. Postnatal muscle grows and adapts largely by remodelling pre-existing fibres, whereas embryonic muscle grows by the proliferation of myogenic cells. Recently, the genetic hierarchies of the myogenic transcription factors that control vertebrate muscle development — by myoblast proliferation, migration, fusion and functional adaptation into fast-twitch and slow-twitch fibres — have become clearer. The transcriptional mechanisms controlling postnatal hypertrophic growth, remodelling and functional differentiation redeploy myogenic factors in concert with serum response factor (SRF), JUNB and forkhead box protein O3A (FOXO3A). It has also emerged that there is extensive post-transcriptional regulation by microRNAs in development and postnatal remodelling.