Wednesday, May 18, 2011

Hot off the presses! Jun 01 Nat Genet

The Jun 01 issue of the Nat Genet is now up on Pubget (About Nat Genet): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

  • Remembering things past
    - Nat Genet 12(6):461 (2011)
    Nature Immunology | Editorial Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Remembering things past Journal name:Nature ImmunologyVolume: 12,Page:461Year published:(2011)DOI:doi:10.1038/ni0611-461Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Memory is the signature property of the adaptive response, and vaccination is a hugely important medical intervention—understanding the former will help perfect the latter. View full text Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • Understand memory, design better vaccines
    - Nat Genet 12(6):463-465 (2011)
    Nature Immunology | Overview Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Understand memory, design better vaccines * Michael J Bevan1Journal name:Nature ImmunologyVolume: 12,Pages:463–465Year published:(2011)DOI:doi:10.1038/ni.2041Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Naive lymphocytes have a finite lifespan and are continually replaced by input from generative organs. In contrast, memory cells or their progeny can last a lifetime. The expanded populations of memory cells and their more widespread distribution provide protection against recurrent infection. View full text Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Department of Immunology, University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA. * Michael J Bevan Competing financial interests The author declares no competing financial interests. Corresponding author Correspondence to: * Michael J Bevan Author Details * Michael J Bevan Contact Michael J Bevan Search for this author in: * NPG journals * PubMed * Google Scholar Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • Origins of CD4+ effector and central memory T cells
    - Nat Genet 12(6):467-471 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
    - Nat Genet 12(6):472-477 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells
    - Nat Genet 12(6):478-484 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Regional and mucosal memory T cells
    - Nat Genet 12(6):485-491 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • T cell exhaustion
    - Nat Genet 12(6):492-499 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Natural killer cell memory
    - Nat Genet 12(6):500-508 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Immunological mechanisms of vaccination
    - Nat Genet 12(6):509-517 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Research Highlights
    - Nat Genet 12(6):518 (2011)
    Nature Immunology | Editorial Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Remembering things past Journal name:Nature ImmunologyVolume: 12,Page:461Year published:(2011)DOI:doi:10.1038/ni0611-461Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Memory is the signature property of the adaptive response, and vaccination is a hugely important medical intervention—understanding the former will help perfect the latter. View full text Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • A BATF-ling connection between B cells and follicular helper T cells
    - Nat Genet 12(6):519-520 (2011)
    Nature Immunology | Overview Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Understand memory, design better vaccines * Michael J Bevan1Journal name:Nature ImmunologyVolume: 12,Pages:463–465Year published:(2011)DOI:doi:10.1038/ni.2041Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Naive lymphocytes have a finite lifespan and are continually replaced by input from generative organs. In contrast, memory cells or their progeny can last a lifetime. The expanded populations of memory cells and their more widespread distribution provide protection against recurrent infection. View full text Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Department of Immunology, University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA. * Michael J Bevan Competing financial interests The author declares no competing financial interests. Corresponding author Correspondence to: * Michael J Bevan Author Details * Michael J Bevan Contact Michael J Bevan Search for this author in: * NPG journals * PubMed * Google Scholar Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • GM-CSF: the secret weapon in the TH17 arsenal
    - Nat Genet 12(6):521-522 (2011)
    Nature Immunology | Overview Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Understand memory, design better vaccines * Michael J Bevan1Journal name:Nature ImmunologyVolume: 12,Pages:463–465Year published:(2011)DOI:doi:10.1038/ni.2041Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Naive lymphocytes have a finite lifespan and are continually replaced by input from generative organs. In contrast, memory cells or their progeny can last a lifetime. The expanded populations of memory cells and their more widespread distribution provide protection against recurrent infection. View full text Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Department of Immunology, University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA. * Michael J Bevan Competing financial interests The author declares no competing financial interests. Corresponding author Correspondence to: * Michael J Bevan Author Details * Michael J Bevan Contact Michael J Bevan Search for this author in: * NPG journals * PubMed * Google Scholar Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • Fox factors fight over T cell quiescence
    - Nat Genet 12(6):522-524 (2011)
    Nature Immunology | Overview Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Understand memory, design better vaccines * Michael J Bevan1Journal name:Nature ImmunologyVolume: 12,Pages:463–465Year published:(2011)DOI:doi:10.1038/ni.2041Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Naive lymphocytes have a finite lifespan and are continually replaced by input from generative organs. In contrast, memory cells or their progeny can last a lifetime. The expanded populations of memory cells and their more widespread distribution provide protection against recurrent infection. View full text Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Department of Immunology, University of Washington and Howard Hughes Medical Institute, Seattle, Washington, USA. * Michael J Bevan Competing financial interests The author declares no competing financial interests. Corresponding author Correspondence to: * Michael J Bevan Author Details * Michael J Bevan Contact Michael J Bevan Search for this author in: * NPG journals * PubMed * Google Scholar Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • Research Highlights
    - Nat Genet 12(6):525 (2011)
    Nature Immunology | Editorial Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Remembering things past Journal name:Nature ImmunologyVolume: 12,Page:461Year published:(2011)DOI:doi:10.1038/ni0611-461Published online18 May 2011 Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Memory is the signature property of the adaptive response, and vaccination is a hugely important medical intervention—understanding the former will help perfect the latter. View full text Read the full article * Instant access to this article: US$32Buy now * Subscribe to Nature Immunology for full access: SubscribeLogin for existing subscribers Additional access options: * Use a document delivery service * Login via Athens * Purchase a site license * Institutional access * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data
  • Genetic analysis of basophil function in vivo
    - Nat Genet 12(6):527-535 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
    - Nat Genet 12(6):536-543 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
    - Nat Genet 12(6):544-550 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
    - Nat Genet 12(6):551-559 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • RORĪ³t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    - Nat Genet 12(6):560-567 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
  • The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    - Nat Genet 12(6):568-575 (2011)
    Nature Immunology | Review Immunological memory Focus issue: June 2011 Volume 12, No 6 * * Reviews * Research Highlights * * Contents * Editorial * Overview Origins of CD4+ effector and central memory T cells * Marion Pepper1 * Marc K Jenkins1 * Affiliations * Corresponding authorJournal name:Nature ImmunologyVolume: 131,Pages:467–471Year published:(2011)DOI:doi:10.1038/ni.2038Published online18 May 2011 Abstract * Abstract * Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Lineage-committed effector CD4+ T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (TH1) effector cells survive the contraction phase of the primary response and become effector memory cells. We discuss the applicability of this idea to the TH2 cell, TH17 helper T cell, follicular helper T cell (TFH cell) and induced regulatory T cell lineages. We also discuss how central memory cells are formed, with an emphasis on the role of B cells in this process. View full text Author information * Abstract * Author information Affiliations * Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. * Marion Pepper & * Marc K Jenkins Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Marc K Jenkins Author Details * Marion Pepper Search for this author in: * NPG journals * PubMed * Google Scholar * Marc K Jenkins Contact Marc K Jenkins Search for this author in: * NPG journals * PubMed * Google Scholar Additional data
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