Hot off the presses! Jun 01 Nat Rev Genet

The Jun 01 issue of the Nat Rev Genet is now up on Pubget (About Nat Rev Genet): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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  - Nat Rev Genet 11(6):365 (2011)
  
• T cells: T cell fate in the (im)balance | PDF (168 KB)
  - Nat Rev Genet 11(6):367 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Innate immunity: Linking lipids and inflammasomes | PDF (247 KB)
  - Nat Rev Genet 11(6):368 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Monocytes: Nudged out of the niche | PDF (212 KB)
  - Nat Rev Genet 11(6):368 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Signalling: PI3Kβ — linking signals for neutrophil activation | PDF (103 KB)
  - Nat Rev Genet 11(6):369 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Cytokines: GM-CSF in focus | PDF (152 KB)
  - Nat Rev Genet 11(6):370 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• T cell responses: CD4s work the doors | PDF (261 KB)
  - Nat Rev Genet 11(6):370 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Phagocytosis: A synapse for snaps | PDF (240 KB)
  - Nat Rev Genet 11(6):371 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Antiviral immunity: TRIM5 moonlights as a pattern recognition receptor | PDF (140 KB)
  - Nat Rev Genet 11(6):372 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Innate immunity: GBPs coordinate vesicular trafficking for host defence | PDF (311 KB)
  - Nat Rev Genet 11(6):372 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Transplantation | Co-stimulation | Vaccines | PDF (89 KB)
  - Nat Rev Genet 11(6):372 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Neuroimmunology | NKT cells | Vaccines | PDF (98 KB)
  - Nat Rev Genet 11(6):373 (2011)
  When a T cell encounters its cognate antigen on an antigen-presenting cell, there is a rapid polarization of intracellular and transmembrane proteins towards the site of intercellular contact to form an immune synapse. Subsequent T cell activation leads to T cell proliferation and differentiation towards one of several T cell fates, depending on signals from the environment.
• Diversity and dialogue in immunity to helminths
  - Nat Rev Genet 11(6):375 (2011)
  The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.
• Mitochondria in innate immune responses
  - Nat Rev Genet 11(6):389 (2011)
  The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.
• The outs and the ins of sphingosine-1-phosphate in immunity
  - Nat Rev Genet 11(6):403 (2011)
  The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.
• The insider's guide to leukocyte integrin signalling and function
  - Nat Rev Genet 11(6):416 (2011)
  The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.
• Fibrocytes: emerging effector cells in chronic inflammation
  - Nat Rev Genet 11(6):427 (2011)
  The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.