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- Mapping the money
- Nat Meth 8(6):437 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - The author file
- Nat Meth 8(6):439 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Color blindness
- Nat Meth 8(6):441 (2011)
Article preview View full access options Nature Methods | This Month Color blindness * Bang Wong1Journal name:Nature MethodsVolume: 8,Page:441Year published:(2011)DOI:doi:10.1038/nmeth.1618Published online27 May 2011 Since my first column on color coding1 appeared, we have received a number of e-mails asking us to highlight the issue of color blindness. One of those correspondences was published in the October 2010 issue2. Here I offer guidelines to make graphics accessible to those with color vision deficiencies. Color blindness affects a substantial portion of the human population. Protanopia and deuteranopia, the two most common forms of inherited color blindness, are red-green color vision defects caused by the absence of red or green retinal photoreceptors, respectively. In individuals of Northern European ancestry, as many as 8 percent of men and 0.5 percent of women experience the common form of red-green color blindness3. If a submitted manuscript happens to go to three male reviewers of Northern European descent, the chance that at least one will be color blind is 22 percent. Picking colors suitable for color-blind readers not only enhances accessibility but also is good graphic design practice. For example, the Ishihara color vision test intentionally relies only on color hue to create contrast, as evident when the image is converted to grayscale (Fig. 1a). In general, colors will be easier to distinguish when they vary in lightness and saturation as well as hue (Fig. 1b). The palette of eight colors shown in Figure 2 has good overall variability and can be differentiated by individuals with red-green color blindness. Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Full size image (260 KB) * Figures index * Next figure Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. Figures at a glance * Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. * Figure 3: Red-green color coding in an immunofluorescent image. () Conventional color coding is difficult for individuals with red-green color blindness (protanopia or deuteranopia) to discriminate. () Replacing red with magenta (top) or green with turquoise (bottom) improves visibility for such individuals. Source image from reference 4. Article preview Read the full article * Instant access to this article: US$32 Buy now * Subscribe to Nature Methods for full access: Subscribe * Personal subscribers: Log in Additional access options: * Login via Athens * Login via your Institution * Purchase a site license * Use a document delivery service * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Bang Wong is the creative director of the Broad Institute of the Massachusetts Institute of Technology & Harvard and an adjunct assistant professor in the Department of Art as Applied to Medicine at The Johns Hopkins University School of Medicine. Author Details * Bang Wong Search for this author in: * NPG journals * PubMed * Google Scholar Additional data * Journal home * Current issue * For authors * Subscribe * E-alert sign up * RSS feed Science jobs from naturejobs * Gene Ontology Developer / Curator * European Bioinformatics Institute (EBI) * Cambridge, United Kingdom * Post-doctoral Scientist (m / f) * Boehringer Ingelheim RCV Vienna * Vienna, Austria * Vienna International Post-Doctoral Training in Molecular Life Sciences * Max F. Perutz Laboratories * Wien, Austria * Post a free job * More science jobs Open innovation challenges * Upload Your Compound Libraries! Deadline:Jan 20 2013Reward:See Details As part of our improved Novel Molecules Challenge (NMC) procedure, you may now upload to InnoCenti… * Novel Chemical Derivatives of Bicarbonate Deadline:Jun 02 2011Reward:$20,000 USD The Seeker desires suggestions for novel chemical derivatives of bicarbonate that are water-insolu… * Powered by: * More challenges Top content Emailed * Defining pluripotency Nature Methods 28 Oct 2010 * Light tools Nature Methods 20 Dec 2010 * Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing Nature Methods 06 Feb 2011 * Enzymatic assembly of DNA molecules up to several hundred kilobases Nature Methods 12 Apr 2009 * Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization Nature Methods 17 Feb 2006 View all Downloaded * Fast, three-dimensional super-resolution imaging of live cells Nature Methods 08 May 2011 * Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Nature Methods 04 Mar 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Mapping and quantifying mammalian transcriptomes by RNA-Seq Nature Methods 30 May 2008 * A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins Nature Methods 15 May 2011 View all Blogged * Two-photon absorption properties of fluorescent proteins Nature Methods 28 Apr 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Validation of two ribosomal RNA removal methods for microbial metatranscriptomics Nature Methods 19 Sep 2010 * Microbial community resemblance methods differ in their ability to detect biologically relevant patterns Nature Methods 05 Sep 2010 * Comprehensive comparative analysis of strand-specific RNA sequencing methods Nature Methods 15 Aug 2010 View all * Nature Methods * ISSN: 1548-7091 * EISSN: 1548-7105 * About NPG * Contact NPG * RSS web feeds * Help * Privacy policy * Legal notice * Accessibility statement * Terms * Nature News * Naturejobs * Nature Asia * Nature EducationSearch:Go © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.partner of AGORA, HINARI, OARE, INASP, CrossRef and COUNTER - Database of NIH grants using machine-learned categories and graphical clustering
- Nat Meth 8(6):443-444 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Predicting protein associations with long noncoding RNAs
- Nat Meth 8(6):444-445 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Perfecting ChR2
- Nat Meth 8(6):447 (2011)
Nature Methods | Research Highlights Perfecting ChR2 * Erika PastranaJournal name:Nature MethodsVolume: 8,Page:447Year published:(2011)DOI:doi:10.1038/nmeth0611-447Published online27 May 2011 Two new reports describe variants of channelrhodopsin 2 with improved properties. View full text Subject terms: * Neuroscience Additional data Author Details * Erika Pastrana Search for this author in: * NPG journals * PubMed * Google Scholar - The right chromophore for the job
- Nat Meth 8(6):448-449 (2011)
Nature Methods | Research Highlights The right chromophore for the job * Daniel EvankoJournal name:Nature MethodsVolume: 8,Pages:448–449Year published:(2011)DOI:doi:10.1038/nmeth0611-448aPublished online27 May 2011 A normally undesirable property of chromophores is used in the creation of a genetically encoded tag for correlated light and electron microscopy. View full text Subject terms: * Sensors and probes Additional data Author Details * Daniel Evanko Search for this author in: * NPG journals * PubMed * Google Scholar - From pseudogenes to proteins
- Nat Meth 8(6):448-449 (2011)
Nature Methods | Research Highlights From pseudogenes to proteins * Nicole RuskJournal name:Nature MethodsVolume: 8,Pages:448–449Year published:(2011)DOI:doi:10.1038/nmeth0611-448bPublished online27 May 2011 Combining proteome analysis with genome sequencing improves gene annotation and yields evidence that some genes presumed to be noncoding are actually expressed. View full text Subject terms: * Genomics Additional data Author Details * Nicole Rusk Search for this author in: * NPG journals * PubMed * Google Scholar - News in brief
- Nat Meth 8(6):449 (2011)
Article preview View full access options Nature Methods | Research Highlights News in brief Journal name:Nature MethodsVolume: 8,Page:449Year published:(2011)DOI:doi:10.1038/nmeth0611-449Published online27 May 2011 Genome-wide map of the sixth base Although 5-hyrdoxymethyl-cytosine (5hmC) is thought to be important for genome function in certain cells, a lack of tools has made profiling difficult. Xu et al. used a 5hmC-specific antibody for methylated DNA immunoprecipitation (MeDIP) and found distinct genome-wide 5hmC patterns in the mouse. The researchers saw 5hmC enrichment in gene bodies rather than at promoters and in intergenic regions. They also uncovered a role for the ten-eleven translocation (Tet) family of 5mC hydroxylases. Xu, Y.et al. Mol. Cell. advance online publication (20 April 2011). Article preview Read the full article * FREE access with registration Register now * Already have a Nature.com account? Log in Additional access options: * Login via Athens * Login via your Institution * Purchase a site license * Use a document delivery service * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Additional data - Directed evolution made easy
- Nat Meth 8(6):451 (2011)
Nature Methods | Research Highlights Perfecting ChR2 * Erika PastranaJournal name:Nature MethodsVolume: 8,Page:447Year published:(2011)DOI:doi:10.1038/nmeth0611-447Published online27 May 2011 Two new reports describe variants of channelrhodopsin 2 with improved properties. View full text Subject terms: * Neuroscience Additional data Author Details * Erika Pastrana Search for this author in: * NPG journals * PubMed * Google Scholar - Resurrected enzymes
- Nat Meth 8(6):452 (2011)
Nature Methods | Research Highlights Perfecting ChR2 * Erika PastranaJournal name:Nature MethodsVolume: 8,Page:447Year published:(2011)DOI:doi:10.1038/nmeth0611-447Published online27 May 2011 Two new reports describe variants of channelrhodopsin 2 with improved properties. View full text Subject terms: * Neuroscience Additional data Author Details * Erika Pastrana Search for this author in: * NPG journals * PubMed * Google Scholar - DNA origami in 3D
- Nat Meth 8(6):454 (2011)
Nature Methods | Research Highlights Perfecting ChR2 * Erika PastranaJournal name:Nature MethodsVolume: 8,Page:447Year published:(2011)DOI:doi:10.1038/nmeth0611-447Published online27 May 2011 Two new reports describe variants of channelrhodopsin 2 with improved properties. View full text Subject terms: * Neuroscience Additional data Author Details * Erika Pastrana Search for this author in: * NPG journals * PubMed * Google Scholar - Microarrays, megasynthesis
- Nat Meth 8(6):457-460 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Bringing fly brains in line
- Nat Meth 8(6):461-463 (2011)
Article preview View full access options Nature Methods | This Month Color blindness * Bang Wong1Journal name:Nature MethodsVolume: 8,Page:441Year published:(2011)DOI:doi:10.1038/nmeth.1618Published online27 May 2011 Since my first column on color coding1 appeared, we have received a number of e-mails asking us to highlight the issue of color blindness. One of those correspondences was published in the October 2010 issue2. Here I offer guidelines to make graphics accessible to those with color vision deficiencies. Color blindness affects a substantial portion of the human population. Protanopia and deuteranopia, the two most common forms of inherited color blindness, are red-green color vision defects caused by the absence of red or green retinal photoreceptors, respectively. In individuals of Northern European ancestry, as many as 8 percent of men and 0.5 percent of women experience the common form of red-green color blindness3. If a submitted manuscript happens to go to three male reviewers of Northern European descent, the chance that at least one will be color blind is 22 percent. Picking colors suitable for color-blind readers not only enhances accessibility but also is good graphic design practice. For example, the Ishihara color vision test intentionally relies only on color hue to create contrast, as evident when the image is converted to grayscale (Fig. 1a). In general, colors will be easier to distinguish when they vary in lightness and saturation as well as hue (Fig. 1b). The palette of eight colors shown in Figure 2 has good overall variability and can be differentiated by individuals with red-green color blindness. Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Full size image (260 KB) * Figures index * Next figure Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. Figures at a glance * Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. * Figure 3: Red-green color coding in an immunofluorescent image. () Conventional color coding is difficult for individuals with red-green color blindness (protanopia or deuteranopia) to discriminate. () Replacing red with magenta (top) or green with turquoise (bottom) improves visibility for such individuals. Source image from reference 4. Article preview Read the full article * Instant access to this article: US$32 Buy now * Subscribe to Nature Methods for full access: Subscribe * Personal subscribers: Log in Additional access options: * Login via Athens * Login via your Institution * Purchase a site license * Use a document delivery service * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Bang Wong is the creative director of the Broad Institute of the Massachusetts Institute of Technology & Harvard and an adjunct assistant professor in the Department of Art as Applied to Medicine at The Johns Hopkins University School of Medicine. Author Details * Bang Wong Search for this author in: * NPG journals * PubMed * Google Scholar Additional data * Journal home * Current issue * For authors * Subscribe * E-alert sign up * RSS feed Science jobs from naturejobs * Gene Ontology Developer / Curator * European Bioinformatics Institute (EBI) * Cambridge, United Kingdom * Post-doctoral Scientist (m / f) * Boehringer Ingelheim RCV Vienna * Vienna, Austria * Vienna International Post-Doctoral Training in Molecular Life Sciences * Max F. Perutz Laboratories * Wien, Austria * Post a free job * More science jobs Open innovation challenges * Upload Your Compound Libraries! Deadline:Jan 20 2013Reward:See Details As part of our improved Novel Molecules Challenge (NMC) procedure, you may now upload to InnoCenti… * Novel Chemical Derivatives of Bicarbonate Deadline:Jun 02 2011Reward:$20,000 USD The Seeker desires suggestions for novel chemical derivatives of bicarbonate that are water-insolu… * Powered by: * More challenges Top content Emailed * Defining pluripotency Nature Methods 28 Oct 2010 * Light tools Nature Methods 20 Dec 2010 * Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing Nature Methods 06 Feb 2011 * Enzymatic assembly of DNA molecules up to several hundred kilobases Nature Methods 12 Apr 2009 * Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization Nature Methods 17 Feb 2006 View all Downloaded * Fast, three-dimensional super-resolution imaging of live cells Nature Methods 08 May 2011 * Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Nature Methods 04 Mar 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Mapping and quantifying mammalian transcriptomes by RNA-Seq Nature Methods 30 May 2008 * A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins Nature Methods 15 May 2011 View all Blogged * Two-photon absorption properties of fluorescent proteins Nature Methods 28 Apr 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Validation of two ribosomal RNA removal methods for microbial metatranscriptomics Nature Methods 19 Sep 2010 * Microbial community resemblance methods differ in their ability to detect biologically relevant patterns Nature Methods 05 Sep 2010 * Comprehensive comparative analysis of strand-specific RNA sequencing methods Nature Methods 15 Aug 2010 View all * Nature Methods * ISSN: 1548-7091 * EISSN: 1548-7105 * About NPG * Contact NPG * RSS web feeds * Help * Privacy policy * Legal notice * Accessibility statement * Terms * Nature News * Naturejobs * Nature Asia * Nature EducationSearch:Go © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.partner of AGORA, HINARI, OARE, INASP, CrossRef and COUNTER - Channeling the data deluge
- Nat Meth 8(6):463-465 (2011)
Article preview View full access options Nature Methods | This Month Color blindness * Bang Wong1Journal name:Nature MethodsVolume: 8,Page:441Year published:(2011)DOI:doi:10.1038/nmeth.1618Published online27 May 2011 Since my first column on color coding1 appeared, we have received a number of e-mails asking us to highlight the issue of color blindness. One of those correspondences was published in the October 2010 issue2. Here I offer guidelines to make graphics accessible to those with color vision deficiencies. Color blindness affects a substantial portion of the human population. Protanopia and deuteranopia, the two most common forms of inherited color blindness, are red-green color vision defects caused by the absence of red or green retinal photoreceptors, respectively. In individuals of Northern European ancestry, as many as 8 percent of men and 0.5 percent of women experience the common form of red-green color blindness3. If a submitted manuscript happens to go to three male reviewers of Northern European descent, the chance that at least one will be color blind is 22 percent. Picking colors suitable for color-blind readers not only enhances accessibility but also is good graphic design practice. For example, the Ishihara color vision test intentionally relies only on color hue to create contrast, as evident when the image is converted to grayscale (Fig. 1a). In general, colors will be easier to distinguish when they vary in lightness and saturation as well as hue (Fig. 1b). The palette of eight colors shown in Figure 2 has good overall variability and can be differentiated by individuals with red-green color blindness. Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Full size image (260 KB) * Figures index * Next figure Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. Figures at a glance * Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. * Figure 3: Red-green color coding in an immunofluorescent image. () Conventional color coding is difficult for individuals with red-green color blindness (protanopia or deuteranopia) to discriminate. () Replacing red with magenta (top) or green with turquoise (bottom) improves visibility for such individuals. Source image from reference 4. Article preview Read the full article * Instant access to this article: US$32 Buy now * Subscribe to Nature Methods for full access: Subscribe * Personal subscribers: Log in Additional access options: * Login via Athens * Login via your Institution * Purchase a site license * Use a document delivery service * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Bang Wong is the creative director of the Broad Institute of the Massachusetts Institute of Technology & Harvard and an adjunct assistant professor in the Department of Art as Applied to Medicine at The Johns Hopkins University School of Medicine. Author Details * Bang Wong Search for this author in: * NPG journals * PubMed * Google Scholar Additional data * Journal home * Current issue * For authors * Subscribe * E-alert sign up * RSS feed Science jobs from naturejobs * Gene Ontology Developer / Curator * European Bioinformatics Institute (EBI) * Cambridge, United Kingdom * Post-doctoral Scientist (m / f) * Boehringer Ingelheim RCV Vienna * Vienna, Austria * Vienna International Post-Doctoral Training in Molecular Life Sciences * Max F. Perutz Laboratories * Wien, Austria * Post a free job * More science jobs Open innovation challenges * Upload Your Compound Libraries! Deadline:Jan 20 2013Reward:See Details As part of our improved Novel Molecules Challenge (NMC) procedure, you may now upload to InnoCenti… * Novel Chemical Derivatives of Bicarbonate Deadline:Jun 02 2011Reward:$20,000 USD The Seeker desires suggestions for novel chemical derivatives of bicarbonate that are water-insolu… * Powered by: * More challenges Top content Emailed * Defining pluripotency Nature Methods 28 Oct 2010 * Light tools Nature Methods 20 Dec 2010 * Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing Nature Methods 06 Feb 2011 * Enzymatic assembly of DNA molecules up to several hundred kilobases Nature Methods 12 Apr 2009 * Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization Nature Methods 17 Feb 2006 View all Downloaded * Fast, three-dimensional super-resolution imaging of live cells Nature Methods 08 May 2011 * Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Nature Methods 04 Mar 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Mapping and quantifying mammalian transcriptomes by RNA-Seq Nature Methods 30 May 2008 * A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins Nature Methods 15 May 2011 View all Blogged * Two-photon absorption properties of fluorescent proteins Nature Methods 28 Apr 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Validation of two ribosomal RNA removal methods for microbial metatranscriptomics Nature Methods 19 Sep 2010 * Microbial community resemblance methods differ in their ability to detect biologically relevant patterns Nature Methods 05 Sep 2010 * Comprehensive comparative analysis of strand-specific RNA sequencing methods Nature Methods 15 Aug 2010 View all * Nature Methods * ISSN: 1548-7091 * EISSN: 1548-7105 * About NPG * Contact NPG * RSS web feeds * Help * Privacy policy * Legal notice * Accessibility statement * Terms * Nature News * Naturejobs * Nature Asia * Nature EducationSearch:Go © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.partner of AGORA, HINARI, OARE, INASP, CrossRef and COUNTER - All-in-one live: genes trapped, tagged and conditionally broken
- Nat Meth 8(6):466-467 (2011)
Article preview View full access options Nature Methods | This Month Color blindness * Bang Wong1Journal name:Nature MethodsVolume: 8,Page:441Year published:(2011)DOI:doi:10.1038/nmeth.1618Published online27 May 2011 Since my first column on color coding1 appeared, we have received a number of e-mails asking us to highlight the issue of color blindness. One of those correspondences was published in the October 2010 issue2. Here I offer guidelines to make graphics accessible to those with color vision deficiencies. Color blindness affects a substantial portion of the human population. Protanopia and deuteranopia, the two most common forms of inherited color blindness, are red-green color vision defects caused by the absence of red or green retinal photoreceptors, respectively. In individuals of Northern European ancestry, as many as 8 percent of men and 0.5 percent of women experience the common form of red-green color blindness3. If a submitted manuscript happens to go to three male reviewers of Northern European descent, the chance that at least one will be color blind is 22 percent. Picking colors suitable for color-blind readers not only enhances accessibility but also is good graphic design practice. For example, the Ishihara color vision test intentionally relies only on color hue to create contrast, as evident when the image is converted to grayscale (Fig. 1a). In general, colors will be easier to distinguish when they vary in lightness and saturation as well as hue (Fig. 1b). The palette of eight colors shown in Figure 2 has good overall variability and can be differentiated by individuals with red-green color blindness. Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Full size image (260 KB) * Figures index * Next figure Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. Figures at a glance * Figure 1: Ishihara color-vision test plate. () Viewers with normal color vision should see the numeral '6′. () Changing lightness of background improves contrast. * Figure 2: Colors optimized for color-blind individuals. P and D indicate simulated colors as seen by individuals with protanopia and deuteranopia, respectively. * Figure 3: Red-green color coding in an immunofluorescent image. () Conventional color coding is difficult for individuals with red-green color blindness (protanopia or deuteranopia) to discriminate. () Replacing red with magenta (top) or green with turquoise (bottom) improves visibility for such individuals. Source image from reference 4. Article preview Read the full article * Instant access to this article: US$32 Buy now * Subscribe to Nature Methods for full access: Subscribe * Personal subscribers: Log in Additional access options: * Login via Athens * Login via your Institution * Purchase a site license * Use a document delivery service * British Library Document Supply Centre * Infotrieve * Thompson ISI Document Delivery * You can also request this document from your local library through inter-library loan services. Author information Article tools * Full text * Print * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg Affiliations * Bang Wong is the creative director of the Broad Institute of the Massachusetts Institute of Technology & Harvard and an adjunct assistant professor in the Department of Art as Applied to Medicine at The Johns Hopkins University School of Medicine. Author Details * Bang Wong Search for this author in: * NPG journals * PubMed * Google Scholar Additional data * Journal home * Current issue * For authors * Subscribe * E-alert sign up * RSS feed Science jobs from naturejobs * Gene Ontology Developer / Curator * European Bioinformatics Institute (EBI) * Cambridge, United Kingdom * Post-doctoral Scientist (m / f) * Boehringer Ingelheim RCV Vienna * Vienna, Austria * Vienna International Post-Doctoral Training in Molecular Life Sciences * Max F. Perutz Laboratories * Wien, Austria * Post a free job * More science jobs Open innovation challenges * Upload Your Compound Libraries! Deadline:Jan 20 2013Reward:See Details As part of our improved Novel Molecules Challenge (NMC) procedure, you may now upload to InnoCenti… * Novel Chemical Derivatives of Bicarbonate Deadline:Jun 02 2011Reward:$20,000 USD The Seeker desires suggestions for novel chemical derivatives of bicarbonate that are water-insolu… * Powered by: * More challenges Top content Emailed * Defining pluripotency Nature Methods 28 Oct 2010 * Light tools Nature Methods 20 Dec 2010 * Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing Nature Methods 06 Feb 2011 * Enzymatic assembly of DNA molecules up to several hundred kilobases Nature Methods 12 Apr 2009 * Fluorescence protease protection of GFP chimeras to reveal protein topology and subcellular localization Nature Methods 17 Feb 2006 View all Downloaded * Fast, three-dimensional super-resolution imaging of live cells Nature Methods 08 May 2011 * Rapid three-dimensional isotropic imaging of living cells using Bessel beam plane illumination Nature Methods 04 Mar 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Mapping and quantifying mammalian transcriptomes by RNA-Seq Nature Methods 30 May 2008 * A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins Nature Methods 15 May 2011 View all Blogged * Two-photon absorption properties of fluorescent proteins Nature Methods 28 Apr 2011 * Chemically defined conditions for human iPSC derivation and culture Nature Methods 10 Apr 2011 * Validation of two ribosomal RNA removal methods for microbial metatranscriptomics Nature Methods 19 Sep 2010 * Microbial community resemblance methods differ in their ability to detect biologically relevant patterns Nature Methods 05 Sep 2010 * Comprehensive comparative analysis of strand-specific RNA sequencing methods Nature Methods 15 Aug 2010 View all * Nature Methods * ISSN: 1548-7091 * EISSN: 1548-7105 * About NPG * Contact NPG * RSS web feeds * Help * Privacy policy * Legal notice * Accessibility statement * Terms * Nature News * Naturejobs * Nature Asia * Nature EducationSearch:Go © 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.partner of AGORA, HINARI, OARE, INASP, CrossRef and COUNTER - Computational methods for transcriptome annotation and quantification using RNA-seq
- Nat Meth 8(6):469-477 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Next-generation sequencing to generate interactome datasets
- Nat Meth 8(6):478-480 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Combining quantitative proteomics data processing workflows for greater sensitivity
- Nat Meth 8(6):481-483 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Analysis of repetitive DNA in chromosomes by flow cytometry
- Nat Meth 8(6):484-486 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Adaptive informatics for multifactorial and high-content biological data
- Nat Meth 8(6):487-492 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - BrainAligner: 3D registration atlases of Drosophila brains
- Nat Meth 8(6):493-498 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Fast, three-dimensional super-resolution imaging of live cells
- Nat Meth 8(6):499-505 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - In vivo protein trapping produces a functional expression codex of the vertebrate proteome
- Nat Meth 8(6):506-512 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data - Sequence-based identification of 3D structural modules in RNA with RMDetect
- Nat Meth 8(6):513-519 (2011)
Nature Methods | Editorial Mapping the money Journal name:Nature MethodsVolume: 8,Page:437Year published:(2011)DOI:doi:10.1038/nmeth.1623Published online27 May 2011 Improving search tools for NIH grants will increase the transparency of US government–sponsored research and aid those seeking funding. View full text Additional data
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