Hot off the presses! Jun 01 Nat Rev Gen

The Jun 01 issue of the Nat Rev Gen is now up on Pubget (About Nat Rev Gen): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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  - Nat Rev Gen 12(6):377 (2011)
  
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  - Nat Rev Gen 12(6):378 (2011)
  
• Animal models: Mastering RNAi in mice | PDF (243 KB)
  - Nat Rev Gen 12(6):380 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Technology: Go ahead, make my DNA | PDF (240 KB)
  - Nat Rev Gen 12(6):381 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Evolutionary genomics: Fission yeast compared and contrasted | PDF (159 KB)
  - Nat Rev Gen 12(6):381 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Human disease: Something old, something new | PDF (165 KB)
  - Nat Rev Gen 12(6):382 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Transcription: Getting close to the action | PDF (182 KB)
  - Nat Rev Gen 12(6):382 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Recombination | Population genomics | Gene regulation | Metagenomics | PDF (92 KB)
  - Nat Rev Gen 12(6):382 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Genome instabilty | Epigenetics | Genomic variation | Evolution | PDF (86 KB)
  - Nat Rev Gen 12(6):383 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Patricia Jacobs | PDF (131 KB)
  - Nat Rev Gen 12(6):384 (2011)
  In vivo RNAi is a powerful tool for studying gene function, but its application in mice has been limited by the unreliability of methods for making the necessary transgenic animals. These problems have been overcome in a recent paper that reports an economical and efficient approach to generating mice that express short hairpin RNAs (shRNAs), which trigger RNAi.
• Pointing in the right direction: new developments in the field of planar cell polarity
  - Nat Rev Gen 12(6):385 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.
• Mechanisms and functions of Hedgehog signalling across the metazoa
  - Nat Rev Gen 12(6):393 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.
• Understanding systems-level properties: timely stories from the study of clocks
  - Nat Rev Gen 12(6):407 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.
• Using electronic health records to drive discovery in disease genomics
  - Nat Rev Gen 12(6):417 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.
• Regulation of X-chromosome inactivation by the X-inactivation centre
  - Nat Rev Gen 12(6):429 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.
• Pointing in the right direction: new developments in the field of planar cell polarity
  - Nat Rev Gen 12(6):443 (2011)
  Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.