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Thursday, January 21, 2010

Hot off the presses! Feb 01

The Feb 01 issue of the is now up on Pubget (About ): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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Wednesday, April 28, 2010

Hot off the presses! May 01 Nature Reviews Molecular Cell Biology

The May 01 issue of the Nature Reviews Molecular Cell Biology is now up on Pubget (About Nature Reviews Molecular Cell Biology): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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Saturday, September 24, 2011

Hot off the presses! Oct 01 Nat Rev Mol Cell Biol

The Oct 01 issue of the Nat Rev Mol Cell Biol is now up on Pubget (About Nat Rev Mol Cell Biol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:


  • - Nat Rev Mol Cell Biol 12(10):621 (2011)
  • Cell cycle: The division belt | PDF (199 KB)
    - Nat Rev Mol Cell Biol 12(10):622 (2011)
    The ability to visualize chromosome movements during cell division with unprecedented accuracy reveals a new feature of chromosome alignment during prometaphase. In Cell, two studies report that, in both mitosis and meiosis I, chromosomes align into an equatorial ring prior to bi-orientation — the configuration required for chromosome separation, in which kinetochores are stably attached to microtubules from the opposite poles of the spindle — and that the ring arrangement facilitates spindle assembly.
  • Chromatin: Stress inhibits replication through JNK1 signalling | PDF (173 KB)
    - Nat Rev Mol Cell Biol 12(10):623 (2011)
    To protect the integrity of the genome in conditions of environmental stress, cells temporarily inhibit DNA replication. Miotto and Struhl now identify a signalling pathway linking environmental stress to the initiation of DNA replication.
  • Deconstructing dynamin | Tuning CaMKII | PDF (95 KB)
    - Nat Rev Mol Cell Biol 12(10):623 (2011)
    Dynamin-related proteins (DRPs) are multidomain GTPases that can regulate membrane remodelling events. Although DRPs are known to undergo oligomerization and GTP-dependent conformational changes, it is less clear how these properties drive membrane remodelling.
  • Telomeres: Fusing with RNF8 | PDF (180 KB)
    - Nat Rev Mol Cell Biol 12(10):624 (2011)
    The E3 ubiquitin ligase RING finger 8 (RNF8) promotes DNA repair by mediating the assembly of repair complexes at DNA double-strand breaks (DSBs). Peuscher and Jacobs now show that RNF8 has a detrimental role at uncapped telomeres, mediating telomere fusion and promoting genome instability.
  • Cell division: Repo-Man's extra exit strategy | PDF (234 KB)
    - Nat Rev Mol Cell Biol 12(10):624 (2011)
    Protein phosphatase 1γ (PP1γ) is recruited to mitotic chromatin at anaphase by its regulatory subunit Repo-Man (also known as CDCA2), where it promotes dephosphorylation of histone H3 and chromosome decondensation. Vagnarelli et al.
  • Cell death: Linking metabolism to apoptotic sensitivity | PDF (498 KB)
    - Nat Rev Mol Cell Biol 12(10):625 (2011)
    Studies have suggested that specific metabolites contribute to apoptotic resistance, but the mechanism behind this has been unclear. Yi et al.Nα-acetylation), to promote apoptotic resistance.
  • Cell division: CENPA's tail rules the centromere | PDF (140 KB)
    - Nat Rev Mol Cell Biol 12(10):626 (2011)
    The histone H3 variant centromere protein A (CENPA) is essential for centromere and kinetochore formation in eukaryotes, but how it directs their formation was unclear. Now, by generating reconstituted CENPA chromatin in vitro, Guse et al.
  • Cell signalling | Plant cell biology | Cell signalling | PDF (97 KB)
    - Nat Rev Mol Cell Biol 12(10):626 (2011)
    Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling Berndt, J. D.et al. J. Cell Biol., 737–750 (2011)
  • Cell death: Phagocytes whet their appetite | PDF (178 KB)
    - Nat Rev Mol Cell Biol 12(10):627 (2011)
    The engulfment ability of a phagocyte is controlled by its mitochondrial membrane potential (MMP), according to a study by Ravichandran and colleagues.
  • Membrane dynamics: ER marks the spot | PDF (153 KB)
    - Nat Rev Mol Cell Biol 12(10):627 (2011)
    The endoplasmic reticulum (ER) and mitochondria are known to be intimate, showing stable contacts that can affect lipid synthesis and calcium signalling between the two organelles. The Voeltz laboratory, in collaboration with the Nunnari laboratory, has followed the relative dynamics of these organelles more closely and found that ER contact with mitochondria may actively trigger mitochondrial constriction and subsequent division.
  • Deciphering arginine methylation: Tudor tells the tale
    - Nat Rev Mol Cell Biol 12(10):629 (2011)
    Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has pivotal roles in the formation of complexes that are involved in cellular regulation, including in the generation of small RNAs. Arginine methylation was discovered half a century ago, but the ability of methylarginine sites to serve as binding motifs for members of the Tudor protein family, and the functional significance of the protein–protein interactions that are mediated by Tudor domains, has only recently been appreciated. Tudor proteins are now known to be present in PIWI complexes, where they are thought to interact with methylated PIWI proteins and regulate the PIWI-interacting RNA (piRNA) pathway in the germ line.
  • Dynamic niches in the origination and differentiation of haematopoietic stem cells
    - Nat Rev Mol Cell Biol 12(10):643 (2011)
    Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells. HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic 'niche', or microenvironment. Recent discoveries, aided in part by technological advances in in vivo imaging, have engendered a new appreciation for the dynamic nature of the niche, identifying novel cellular and acellular niche components and uncovering fluctuations in the relative importance of these components over time. These new insights significantly improve our understanding of haematopoiesis and raise fundamental questions about what truly constitutes a stem cell niche.
  • Proteins on the move: insights gained from fluorescent protein technologies
    - Nat Rev Mol Cell Biol 12(10):656 (2011)
    Proteins are always on the move, and this may occur through diffusion or active transport. The realization that the regulation of signal transduction is highly dynamic in space and time has stimulated intense interest in the movement of proteins. Over the past decade, numerous new technologies using fluorescent proteins have been developed, allowing us to observe the spatiotemporal dynamics of proteins in living cells. These technologies have greatly advanced our understanding of protein dynamics, including protein movement and protein interactions.
  • A decade of molecular cell biology: achievements and challenges
    - Nat Rev Mol Cell Biol 12(10):669 (2011)
    Nature Reviews Molecular Cell Biology celebrated its 10-year anniversary during this past year with a series of specially commissioned articles. To complement this, here we have asked researchers from across the field for their insights into how molecular cell biology research has evolved during this past decade, the key concepts that have emerged and the most promising interfaces that have developed. Their comments highlight the broad impact that particular advances have had, some of the basic understanding that we still require, and the collaborative approaches that will be essential for driving the field forward.
  • Insights into autotaxin: how to produce and present a lipid mediator
    - Nat Rev Mol Cell Biol 12(10):674 (2011)
    Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein (G protein)-coupled receptors to stimulate migration, proliferation, survival and other functions in many cell types. ATX is important in vivo for processes as diverse as vasculogenesis, lymphocyte trafficking and tumour progression. However, the inner workings of ATX have long been elusive, in terms of both its substrate specificity and how localized LPA signalling is achieved. Structural studies have shown how ATX recognizes its substrates and may interact with the cell surface to promote specificity in LPA signalling.
  • Discovering pluripotency: 30 years of mouse embryonic stem cells
    - Nat Rev Mol Cell Biol 12(10):680 (2011)
    Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.
  • The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation
    - Nat Rev Mol Cell Biol 12(10):686 (2011)
    Nature Reviews Molecular Cell Biology12, 605–620 (2011) On page 619 of the above article, there was a mistake in the highlighted reference comment under reference 54: "53" in the second sentence should have been "54" ("Reference 54 is the first clear example of the targeting of one E3 family by another."). We apologize for any confusion caused to readers.
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Wednesday, June 23, 2010

Hot off the presses! Jul 01 Nat Rev Mol Cell Biol

The Jul 01 issue of the Nat Rev Mol Cell Biol is now up on Pubget (About Nat Rev Mol Cell Biol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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Friday, July 22, 2011

Hot off the presses! Aug 01 Nat Rev Mol Cell Biol

The Aug 01 issue of the Nat Rev Mol Cell Biol is now up on Pubget (About Nat Rev Mol Cell Biol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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Friday, January 21, 2011

Hot off the presses! Feb 01 Nat Rev Mol Cell Biol

The Feb 01 issue of the Nat Rev Mol Cell Biol is now up on Pubget (About Nat Rev Mol Cell Biol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:


  • - Nat Rev Mol Cell Biol 12(2):71 (2011)
  • Membrane trafficking: A GSK3 lockdown | PDF (322 KB)
    - Nat Rev Mol Cell Biol 12(2):72 (2011)
    A vital step in the WNT signalling pathway is inhibition of glycogen synthase kinase 3 (GSK3), but how this takes place had remained elusive. It turns out that activation of WNT signalling drives GSK3 into multivesicular bodies (MVBs), effectively locking it away from cytosolic substrates.
  • Cytoskeleton: N-WASP 'muscles in' on actin nucleation | PDF (184 KB)
    - Nat Rev Mol Cell Biol 12(2):73 (2011)
    Muscle maturation and hypertrophy require the activation of protein synthesis and myofibrillogenesis. Takano et al.
  • 'Tit-for-tat' in cell biology | PDF (142 KB)
    - Nat Rev Mol Cell Biol 12(2):73 (2011)
    Although my colleagues (and, hopefully, readers) value the importance of evolutionary theory in biology, many of us fail to incorporate it into our research. Therefore, I am going to tell you about a paper that influenced me long ago.
  • Cell migration: MTORC2 brings up the rear | PDF (191 KB)
    - Nat Rev Mol Cell Biol 12(2):74 (2011)
    Target of rapamycin complex 2 (TORC2) is known to have a role in the chemotaxis of Dictyostelium discoideum, and its mammalian counterpart, mTORC2, regulates cytoskeletal reorganization in some cell lines. Parent and colleagues now find that mTORC2 also has a role in neutrophil chemotaxis through control of cell-rear retraction.
  • Cell migration: Keeping together | PDF (207 KB)
    - Nat Rev Mol Cell Biol 12(2):74 (2011)
    Collective cell movement — needed for normal development but also associated with the invasion of cancer cells — requires organization and coordination. An actomyosin force around the edge of a migrating cell cluster facilitates coordinated movement, but contractility at cell–cell contacts inside the cluster must be reduced to maintain group cohesion.
  • Cell signalling: Targeting kinases | PDF (129 KB)
    - Nat Rev Mol Cell Biol 12(2):75 (2011)
    The spatial regulation of signalling pathways is partly controlled by protein domains that mediate intermolecular interactions. Human MARK (MAP/microtubule affinity-regulating kinases) and PAR1 (partitioning-defective 1) Ser/Thr kinases harbour a kinase-associated 1 (KA1) domain, which has no assigned function.
  • Cell signalling: Weighing up TGFβ signals | PDF (145 KB)
    - Nat Rev Mol Cell Biol 12(2):76 (2011)
    Signalling through the Hippo pathway allows sensing of local cell density and subsequent control of cell growth, proliferation and apoptosis. The transcriptional regulators TAZ and YAP are key components in this response, and Varelas et al.
  • Development: A new move for PRMT5 | PDF (178 KB)
    - Nat Rev Mol Cell Biol 12(2):76 (2011)
    To establish and maintain pluripotency, cells must tightly regulate gene expression. Protein Arg N-methyltransferase 5 (PRMT5) is crucial for the development of primordial germ cells, and there have been suggestions that it might also be involved in embryonic stem (ES) cell pluripotency.
  • Gene expression | Autophagy | Stem cells | PDF (127 KB)
    - Nat Rev Mol Cell Biol 12(2):76 (2011)
    Selective silencing of mutated mRNAs in DM1 by using modified hU7-snRNAs François, V.et al. Nature Struct. Mol. Biol. 18, 85–87 (2011)
  • Autophagy: Myosin II moves in on autophagosomes | PDF (135 KB)
    - Nat Rev Mol Cell Biol 12(2):77 (2011)
    During starvation-induced autophagy, cytosol or organelles are engulfed by autophagosomes, the contents of which are degraded by lysosomes and released as nutrients. The kinase Autophagy-related 1 (ATG1) is important for autophagosome formation, but its exact role was unclear.
  • Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
    - Nat Rev Mol Cell Biol 12(2):79 (2011)
    The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state (reprogramming) but can also induce the cell to proliferate (dedifferentiation) or even switch to another cell type (transdifferentiation). Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine.
  • The MRE11 complex: starting from the ends
    - Nat Rev Mol Cell Biol 12(2):90 (2011)
    The maintenance of genome stability depends on the DNA damage response (DDR), which is a functional network comprising signal transduction, cell cycle regulation and DNA repair. The metabolism of DNA double-strand breaks governed by the DDR is important for preventing genomic alterations and sporadic cancers, and hereditary defects in this response cause debilitating human pathologies, including developmental defects and cancer. The MRE11 complex, composed of the meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin) proteins is central to the DDR, and recent insights into its structure and function have been gained from in vitro structural analysis and studies of animal models in which the DDR response is deficient.
  • Feedback regulation of EGFR signalling: decision making by early and delayed loops
    - Nat Rev Mol Cell Biol 12(2):104 (2011)
    Human-made information relay systems invariably incorporate central regulatory components, which are mirrored in biological systems by dense feedback and feedforward loops. This type of system control is exemplified by positive and negative feedback loops (for example, receptor endocytosis and dephosphorylation) that enable growth factors and receptor Tyr kinases of the epidermal growth factor receptor (EGFR)/ERBB family to regulate cellular function. Recent studies show that the collection of feedback regulatory loops can perform computational tasks — such as decoding ligand specificity, transforming graded input signals into a digital output and regulating response kinetics. Aberrant signal processing and feedback regulation can lead to defects associated with pathologies such as cancer.
  • Origins of regulated cell-to-cell variability
    - Nat Rev Mol Cell Biol 12(2):119 (2011)
    Single-cell measurements and lineage-tracing experiments are revealing that phenotypic cell-to-cell variability is often the result of deterministic processes, despite the existence of intrinsic noise in molecular networks. In most cases, this determinism represents largely uncharacterized molecular regulatory mechanisms, which places the study of cell-to-cell variability in the realm of molecular cell biology. Further research in the field will be important to advance quantitative cell biology because it will provide new insights into the mechanisms by which cells coordinate their intracellular activities in the spatiotemporal context of the multicellular environment.
  • The elusive nature and function of mesenchymal stem cells
    - Nat Rev Mol Cell Biol 12(2):126 (2011)
    Mesenchymal stem cells (MSCs) are a diverse subset of multipotent precursors present in the stromal fraction of many adult tissues and have drawn intense interest from translational and basic investigators. MSCs have been operationally defined by their ability to differentiate into osteoblasts, adipocytes and chondrocytes after in vitro expansion. Nevertheless, their identity in vivo, heterogeneity, anatomical localization and functional roles in adult tissue homeostasis have remained enigmatic and are only just starting to be uncovered.
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