Hot off the presses! Feb 01

The Feb 01 issue of the is now up on Pubget (About ): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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  - Nature reviews. Molecular cell biology 11(2):83 (2010)
  Life is complex, even for a eukaryotic cell. For example, whenever a cell divides and gives rise to two daughter cells, it must faithfully duplicate its genome, ensure that the two resulting genome copies are correctly distributed to the daughter cells and then complete the cell cycle by dividing the cytoplasm through cytokinesis.
• DNA damage response: DNA takes a break with SUMO | PDF (225 KB)
  - Nature reviews. Molecular cell biology 11(2):85 (2010)
  PIAS1 and PIAS4 promote BRCA1 sumoylation and DNA repair.
• Lipid trafficking: Exchange by ORDer | PDF (199 KB)
  - Nature reviews. Molecular cell biology 11(2):86 (2010)
  ORPs bind two membranes simultaneously and regulate sterol transfer between them.
• Cancer biology: Motion capture | PDF (247 KB)
  - Nature reviews. Molecular cell biology 11(2):86 (2010)
  Mutant p53 promotes cell invasion through integrin recycling.
• Epigenetics: Unravelling demethylation | PDF (429 KB)
  - Nature reviews. Molecular cell biology 11(2):87 (2010)
  AID and elongator complexes are crucial for mammalian DNA demethylation.
• Cell signalling: It's good to talk | PDF (200 KB)
  - Nature reviews. Molecular cell biology 11(2):88 (2010)
  Cell-specific signalling networks during the interaction between cells.
• Endocytosis: Acetylation controls EGF traffic | PDF (209 KB)
  - Nature reviews. Molecular cell biology 11(2):88 (2010)
  The deacetylase HDAC6 regulates the endocytic trafficking of EGFR.
• Small RNAs: Size control | PDF (229 KB)
  - Nature reviews. Molecular cell biology 11(2):88 (2010)
  miR-8 positively regulates Drosophila melanogaster body size.
• Transcription | Cell cycle | Molecular motors | PDF (161 KB)
  - Nature reviews. Molecular cell biology 11(2):89 (2010)
  Transcription H2A.Z-containing nucleosomes mediate the thermosensory response in Arabidopsis Kumar, S. V. & Wigge, P. A. Cell 140, 136–147 (2010) Plant development adapts to temperature variations.
• RNA silencing sorted | PDF (182 KB)
  - Nature reviews. Molecular cell biology 11(2):90 (2010)
  Understanding the mechanism of siRNA-mediated gene silencing.
• DNA damage response: Bridging genomic instability disorders | PDF (247 KB)
  - Nature reviews. Molecular cell biology 11(2):90 (2010)
  The Fanconi anaemia protein FANCM links two genome instability disorders.
• Mechanisms of chromosome behaviour during mitosis
  - Nature reviews. Molecular cell biology 11(2):91 (2010)
  For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.
• PKC and the control of localized signal dynamics
  - Nature reviews. Molecular cell biology 11(2):103 (2010)
  Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, have been increasingly implicated in the organization of signal propagation, particularly in the spatial distribution of signals. Examples of where and how various PKC isoforms direct this tier of signal organization are becoming more evident.
• The mechanism of eukaryotic translation initiation and principles of its regulation
  - Nature reviews. Molecular cell biology 11(2):113 (2010)
  Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation complexes, have advanced our understanding of the complex translation initiation process. These developments have provided a solid foundation for studying the regulation of translation initiation by mechanisms that include the modulation of initiation factor activity (which affects almost all scanning-dependent initiation) and through sequence-specific RNA-binding proteins and microRNAs (which affect individual mRNAs).
• Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis
  - Nature reviews. Molecular cell biology 11(2):128 (2010)
  The swinging crossbridge hypothesis states that energy from ATP hydrolysis is transduced to mechanical movement of the myosin head while bound to actin. The light chain-binding region of myosin is thought to act as a lever arm that amplifies movements near the catalytic site. This model has been challenged by findings that myosin VI takes larger steps along actin filaments than early interpretations of its structure seem to allow. We now know that myosin VI does indeed operate by an unusual ~ 180° lever arm swing and achieves its large step size using special structural features in its tail domain.
• BRCA1 and its toolbox for the maintenance of genome integrity
  Huen MS Sy SM Chen J - Nature reviews. Molecular cell biology 11(2):138 (2010)
  The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic and genetic studies have revealed the presence of distinct BRCA1 complexes in vivo, each of which governs a specific cellular response to DNA damage. Thus, BRCA1 is emerging as the master regulator of the genome through its ability to execute and coordinate various aspects of the DNA damage response.
• Understanding cytokinesis: lessons from fission yeast
  - Nature reviews. Molecular cell biology 11(2):149 (2010)
  For decades after the discovery that a contractile ring made of actin filaments and myosin II produces the force to constrict the cleavage furrow of animal cells, the complexity of cytokinesis has slowed progress in understanding the mechanism. Mechanistic insights, however, have been obtained by genetic, biochemical, microscopic and mathematical modelling approaches in the fission yeast Schizosaccharomyces pombe. Many features that have been identified in fission yeast are probably shared with animal cells, as both inherited many cytokinesis genes from their common ancestor about one billion years ago.