Hot off the presses! May 01 Nat Rev Genet

The May 01 issue of the Nat Rev Genet is now up on Pubget (About Nat Rev Genet): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

• 
  - Nat Rev Genet 12(5):295 (2011)
  
• 
  - Nat Rev Genet 12(5):296 (2011)
  
• 
  - Nat Rev Genet 12(5):297 (2011)
  
• 
  - Nat Rev Genet 12(5):297 (2011)
  
• 
  - Nat Rev Genet 12(5):298 (2011)
  
• 
  - Nat Rev Genet 12(5):298 (2011)
  
• Evolution | Development | Epigenetics | PDF (81 KB)
  - Nat Rev Genet 12(5):298 (2011)
  Bacteria–phage antagonistic coevolution in soil Gómez, P. & Buckling, A.Science 332, 106–109 (2011)
• Community genetics | Small RNAs | Gene expression | Genomics | PDF (84 KB)
  - Nat Rev Genet 12(5):299 (2011)
  Community genetics: at the crossroads of ecology and evolutionary genetics Phil. Trans. R. Soc. Bhttp://rstb.royalsocietypublishing.org/content/366/1569.toc
• 
  - Nat Rev Genet 12(5):300 (2011)
  
• 
  - Nat Rev Genet 12(5):300 (2011)
  
• Ex vivo gene transfer and correction for cell-based therapies
  - Nat Rev Genet 12(5):301 (2011)
  Cell-based therapies are fast-growing forms of personalized medicine that make use of the steady advances in stem cell manipulation and gene transfer technologies. In this Review, I highlight the latest developments and the crucial challenges for this field, with an emphasis on haematopoietic stem cell gene therapy, which is taken as a representative example given its advanced clinical translation. New technologies for gene correction and targeted integration promise to overcome some of the main hurdles that have long prevented progress in this field. As these approaches marry with our growing capacity for genetic reprogramming of mammalian cells, they may fulfil the promise of safe and effective therapies for currently untreatable diseases.
• Heart failure: advances through genomics
  - Nat Rev Genet 12(5):357 (2011)
  Heart failure is an increasingly prevalent and highly lethal disease that is most often caused by underlying pathologies, such as myocardial infarction or hypertension, but it can also be the result of a single gene mutation. Comprehensive genetic and genomic approaches are starting to disentangle the diverse molecular underpinnings of both forms of the disease and promise to yield much-needed novel diagnostic and therapeutic options for specific subtypes of heart failure.
• Genome structural variation discovery and genotyping
  - Nat Rev Genet 12(5):363 (2011)
  Comparisons of human genomes show that more base pairs are altered as a result of structural variation — including copy number variation — than as a result of point mutations. Here we review advances and challenges in the discovery and genotyping of structural variation. The recent application of massively parallel sequencing methods has complemented microarray-based methods and has led to an exponential increase in the discovery of smaller structural-variation events. Some global discovery biases remain, but the integration of experimental and computational approaches is proving fruitful for accurate characterization of the copy, content and structure of variable regions. We argue that the long-term goal should be routine, cost-effective and high quality de novo assembly of human genomes to comprehensively assess all classes of structural variation.
• Correspondence: Concerning epigenetics and inbreeding
  - Nat Rev Genet 12(5):376 (2011)
  In response to the Review by Charlesworth and Willis (The genetics of inbreeding depression. Nature Rev. Genet. 10, 783–796 (2009)