Hot off the presses! Nov 01 Nat Rev Immunol

The Nov 01 issue of the Nat Rev Immunol is now up on Pubget (About Nat Rev Immunol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

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  - Nat Rev Immunol 11(11):713 (2011)
  
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  - Nat Rev Immunol 11(11):714 (2011)
  
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  - Nat Rev Immunol 11(11):715 (2011)
  
• T cell memory: The stem of T cell memory | PDF (283 KB)
  - Nat Rev Immunol 11(11):716 (2011)
  
• B cell signalling: Right place, right time | PDF (150 KB)
  - Nat Rev Immunol 11(11):716 (2011)
  
• T cell memory: Exhausted T cells miss out on methylation | PDF (190 KB)
  - Nat Rev Immunol 11(11):718 (2011)
  
• Tumour immunology: IFNs boost cancer killers | PDF (235 KB)
  - Nat Rev Immunol 11(11):718 (2011)
  
• Immune tolerance: Suicide is painless | PDF (437 KB)
  - Nat Rev Immunol 11(11):719 (2011)
  
• T cells: Lymphoid stroma says NO to activated T cells | PDF (211 KB)
  - Nat Rev Immunol 11(11):720 (2011)
  
• Neuroimmunology: Nervous ChAT | PDF (208 KB)
  - Nat Rev Immunol 11(11):720 (2011)
  
• Mucosal immunology: Colonic creatures are TReg teachers | PDF (317 KB)
  - Nat Rev Immunol 11(11):721 (2011)
  
• Macrophages: Arteriogenic macrophages protect against ischaemia | PDF (124 KB)
  - Nat Rev Immunol 11(11):716 (2011)
  This study showed that a lower level of expression of the oxygen-sensing molecule PHD2 (also known as EGLN1) by macrophages (in Phd2+/− mice) can protect against ischaemic damage to heart and skeletal muscle by increasing the number of collateral arterial vessels at baseline and by 'preconditioning' these vessels for remodelling (arteriogenesis). Phd2+/− macrophages have a gene expression signature similar to that of M2 macrophages (which promote wound healing and angiogenesis) and produce soluble factors that increase the migration and proliferation of smooth muscle cells. This skewing of Phd2+/− macrophages was shown to depend on activation of the canonical nuclear factor-κB pathway, which is negatively regulated by PHD2 at high oxygen concentrations. Therefore, therapeutic inhibition of PHD2 might be used to promote macrophage-mediated collateral vascularization in patients at risk of ischaemia.
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  - Nat Rev Immunol 11(11):716 (2011)
  
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  - Nat Rev Immunol 11(11):716 (2011)
  
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  - Nat Rev Immunol 11(11):717 (2011)
  
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  - Nat Rev Immunol 11(11):717 (2011)
  
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  - Nat Rev Immunol 11(11):717 (2011)
  
• Protective and pathogenic functions of macrophage subsets
  - Nat Rev Immunol 11(11):723 (2011)
  Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.