Hot off the presses! Jul 01 Nat Rev Mol Cell Biol

The Jul 01 issue of the Nat Rev Mol Cell Biol is now up on Pubget (About Nat Rev Mol Cell Biol): if you're at a subscribing institution, just click the link in the latest link at the home page. (Note you'll only be able to get all the PDFs in the issue if your institution subscribes to Pubget.)

Latest Articles Include:

• From the editors
  - Nat Rev Mol Cell Biol 11(7):459 (2010)
  Music is brought to Nature Reviews Molecular Cell Biology this month, with Joel G. Belasco on page 467 linking classic song titles with molecular mechanisms of mRNA decay in bacteria and eukaryotes. In the 'Shapes of things' and 'Go your own way' sections, he discusses how mRNA breakdown seems to follow different principles in the two kingdoms, based on mRNA structural features and the degradative enzymes involved, respectively.
• Small RNAs: Dispensable Dicer
  - Nat Rev Mol Cell Biol 11(7):461 (2010)
  Two groups identify an alternative miRNA biogenesis pathway.
• Stem cells: 'Cheating' cell death
  David R - Nat Rev Mol Cell Biol 11(7):462 (2010)
  Bulge stem cells are resistant to DNA damage-induced cell death.
• Intracellular transport: RAN goes global
  Heinrichs A - Nat Rev Mol Cell Biol 11(7):462 (2010)
  Ciliary and nuclear import pathways use similar mechanisms.
• Technology Watch: Nucleosome turnover, N-glycosylation mapped
  - Nat Rev Mol Cell Biol 11(7):462 (2010)
  Nucleosome turnover Nucleosome disassembly and reassembly have been difficult to study. Previous approaches have included the mapping of histone variant H3.
• One stop shop
  - Nat Rev Mol Cell Biol 11(7):463 (2010)
  http://www.ebi.
• Autophagy: From one membrane to another
  Wrighton KH - Nat Rev Mol Cell Biol 11(7):464 (2010)
  The mitochondrial outer membrane is a source of starvation-induced autophagosomes.
• Autophagy: Kinase ups and downs
  Wrighton KH - Nat Rev Mol Cell Biol 11(7):464 (2010)
  CDKs regulate autophagy by phosphorylating and inactivating VPS34.
• Cell migration: Moving in 3D
  Baumann K - Nat Rev Mol Cell Biol 11(7):465 (2010)
  Focal adhesion proteins regulate motility in 3D by controlling pseudopodia formation.
• In brief: Cytoskeleton, Autophagy, DNA repair
  - Nat Rev Mol Cell Biol 11(7):465 (2010)
  Cytoskeleton Tubulin polyglutamylation stimulates spastin-mediated microtubule severing Lacroix, B. et al. J. Cell Biol. 7 Jun 2010 (doi: 10.
• The changing faces of cancer cells
  Feng XH - Nat Rev Mol Cell Biol 11(7):466 (2010)
  Cancer stem cells might arise by the epithelial-to-mesenchymal transition.
• Endocytosis: Curvature proteins direct traffic
  - Nat Rev Mol Cell Biol 11(7):466 (2010)
  FCHO proteins select the location for clathrin-coated pit formation.
• All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay
  Belasco JG - Nat Rev Mol Cell Biol 11(7):467 (2010)
  Despite its universal importance for controlling gene expression, mRNA degradation was initially thought to occur by disparate mechanisms in eukaryotes and bacteria. This conclusion was based on differences in the structures used by these organisms to protect mRNA termini and in the RNases and modifying enzymes originally implicated in mRNA decay. Subsequent discoveries have identified several striking parallels between the cellular factors and molecular events that govern mRNA degradation in these two kingdoms of life. Nevertheless, some key distinctions remain, the most fundamental of which may be related to the different mechanisms by which eukaryotes and bacteria control translation initiation.
• Ubiquitin signalling in DNA replication and repair
  Ulrich HD Walden H - Nat Rev Mol Cell Biol 11(7):479 (2010)
  Post-translational modification by ubiquitin is best known for its role in targeting its substrates for regulated degradation. However, non-proteolytic functions of the ubiquitin system, often involving either monoubiquitylation or polyubiquitylation through Lys63-linked chains, have emerged in various cell signalling pathways. These two forms of the ubiquitin signal contribute to three different pathways related to the maintenance of genome integrity that are responsible for the processing of DNA double-strand breaks, the repair of interstrand cross links and the bypass of lesions during DNA replication.
• The nuclear pore complex: bridging nuclear transport and gene regulation
  - Nat Rev Mol Cell Biol 11(7):490 (2010)
  Although the nuclear pore complex (NPC) is best known for its primary function as the key regulator of molecular traffic between the cytoplasm and the nucleus, a growing body of experimental evidence suggests that this structure participates in a considerably broader range of cellular activities on both sides of the nuclear envelope. Indeed, the NPC is emerging as an important regulator of gene expression through its influence on the internal architectural organization of the nucleus and its apparently extensive involvement in coordinating the seamless delivery of genetic information to the cytoplasmic protein synthesis machinery.
• Adherens junctions: from molecules to morphogenesis
  - Nat Rev Mol Cell Biol 11(7):502 (2010)
  How adhesive interactions between cells generate and maintain animal tissue structure remains one of the most challenging and long-standing questions in cell and developmental biology. Adherens junctions (AJs) and the cadherin–catenin complexes at their core are therefore the subjects of intense research. Recent work has greatly advanced our understanding of the molecular organization of AJs and how cadherin–catenin complexes engage actin, microtubules and the endocytic machinery. As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis.
• HSP90 at the hub of protein homeostasis: emerging mechanistic insights
  Taipale M Jarosz DF Lindquist S - Nat Rev Mol Cell Biol 11(7):515 (2010)
  Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins (known as clients). Clients are enriched in signal transducers, including kinases and transcription factors. Therefore, HSP90 regulates diverse cellular functions and exerts marked effects on normal biology, disease and evolutionary processes. Recent structural and functional analyses have provided new insights on the transcriptional and biochemical regulation of HSP90 and the structural dynamics it uses to act on a diverse client repertoire. Comprehensive understanding of how HSP90 functions promises not only to provide new avenues for therapeutic intervention, but to shed light on fundamental biological questions.
• A membranous spindle matrix orchestrates cell division
  Zheng Y - Nat Rev Mol Cell Biol 11(7):529 (2010)
  Eukaryotic cell division uses morphologically different forms of mitosis, referred to as open, partially open and closed mitosis, for accurate chromosome segregation and proper partitioning of other cellular components such as endomembranes and cell fate determinants. Recent studies suggest that the spindle matrix provides a conserved strategy to coordinate the segregation of genetic material and the partitioning of the rest of the cellular contents in all three forms of mitosis.