Latest Articles Include:
- From the editors
- Nat Rev Mol Cell Biol 11(6):385 (2010)
Cells process external cues through signalling pathways to respond to their environment, and pathway dysfunction is often associated with diseases. Cells must simultaneously integrate many signals to regulate responses to environmental changes, so understanding the crosstalk and interplay that occurs is essential when considering therapies that target signalling events. - Cell signalling: Making new connections
Wrighton KH - Nat Rev Mol Cell Biol 11(6):386 (2010)
Recombining protein domains alters the yeast mating pathway. - Sumoylation: Targeting SUMO
- Nat Rev Mol Cell Biol 11(6):387 (2010)
Listeria monocytogenes interferes with host defence pathways by inhibiting sumoylation. - In brief: Small RNAs, Protein structure, Gene expression
- Nat Rev Mol Cell Biol 11(6):387 (2010)
Small RNAs Small RNA duplexes function as mobile silencing signals between plant cells Dunoyer, P. et al. Science 22 Apr 2010 (doi: 10.1126/science. - Cell signalling: Of Rags and Ragulator
Heinrichs A - Nat Rev Mol Cell Biol 11(6):388 (2010)
Ragulator is a new, crucial component of the mTORC1 signalling pathway. - Apoptosis: Which way will the Dicer roll?
Walker D - Nat Rev Mol Cell Biol 11(6):388 (2010)
An unexpected role for the RNase Dicer 1 as a DNase in apoptosis. - Cell cycle: Activities of a mitotic master
- Nat Rev Mol Cell Biol 11(6):389 (2010)
A FRET biosensor reveals how cyclin B1รข€"CDK1 activity coordinates mitotis. - Cell signalling: Regulation and crosstalk
- Nat Rev Mol Cell Biol 11(6):390 (2010)
Molecular links between cell polarity, cell division and cell fate. - Multivariate signal integration
Linding R - Nat Rev Mol Cell Biol 11(6):391 (2010)
The multivariate and integrative nature of signalling networks. - Organelle dynamics: Fusing for stability
Baumann K - Nat Rev Mol Cell Biol 11(6):391 (2010)
Mitochondrial fusion is required for mtDNA mutation tolerance and stability. - Designing customized cell signalling circuits
Lim WA - Nat Rev Mol Cell Biol 11(6):393 (2010)
Living cells have evolved a broad array of complex signalling responses, which enables them to survive diverse environmental challenges and execute specific physiological functions. Our increasingly sophisticated understanding of the molecular mechanisms of cell signalling networks in eukaryotes has revealed a remarkably modular organization and synthetic biologists are exploring how this can be exploited to engineer cells with novel signalling behaviours. This approach is beginning to reveal the logic of how cells might evolve innovative new functions and moves us towards the exciting possibility of engineering custom cells with precise sensing–response functions that could be useful in medicine and biotechnology. - When pathways collide: collaboration and connivance among signalling proteins in development
McNeill H Woodgett JR - Nat Rev Mol Cell Biol 11(6):404 (2010)
Signal transduction pathways interact at various levels to define tissue morphology, size and differentiation during development. Understanding the mechanisms by which these pathways collude has been greatly enhanced by recent insights into how shared components are independently regulated and how the activity of one system is contextualized by others. Traditionally, it has been assumed that the components of signalling pathways show pathway fidelity and act with a high degree of autonomy. However, as illustrated by the Wnt and Hippo pathways, there is increasing evidence that components are often shared between multiple pathways and other components talk to each other through multiple mechanisms. - Signalling ballet in space and time
- Nat Rev Mol Cell Biol 11(6):414 (2010)
Although we have amassed extensive catalogues of signalling network components, our understanding of the spatiotemporal control of emergent network structures has lagged behind. Dynamic behaviour is starting to be explored throughout the genome, but analysis of spatial behaviours is still confined to individual proteins. The challenge is to reveal how cells integrate temporal and spatial information to determine specific biological functions. Key findings are the discovery of molecular signalling machines such as Ras nanoclusters, spatial activity gradients and flexible network circuitries that involve transcriptional feedback. They reveal design principles of spatiotemporal organization that are crucial for network function and cell fate decisions. - Decoding signalling networks by mass spectrometry-based proteomics
Choudhary C Mann M - Nat Rev Mol Cell Biol 11(6):427 (2010)
Signalling networks regulate essentially all of the biology of cells and organisms in normal and disease states. Signalling is often studied using antibody-based techniques such as western blots. Large-scale 'precision proteomics' based on mass spectrometry now enables the system-wide characterization of signalling events at the levels of post-translational modifications, protein–protein interactions and changes in protein expression. This technology delivers accurate and unbiased information about the quantitative changes of thousands of proteins and their modifications in response to any perturbation. Current studies focus on phosphorylation, but acetylation, methylation, glycosylation and ubiquitylation are also becoming amenable to investigation. Large-scale proteomics-based signalling research will fundamentally change our understanding of signalling networks. - Spatial organization of intracellular communication: insights from imaging
Dehmelt L Bastiaens PI - Nat Rev Mol Cell Biol 11(6):440 (2010)
Signal transduction is the transfer of information about the compositional state of the extracellular environment to the intracellular cytoplasm that elicits a morphological or genetic response. In more general terms, this can also be the communication of the state of supramolecular structures, such as the plasma membrane or chromatin, in the cell. This information is relayed through space by the cytoplasm and is mediated by transitions between the steady states of the cytoplasm's reaction networks. To uncover the principles that underlie the generation of spatiotemporal patterns of activity which guide cellular behaviour, functional imaging techniques that report on the activity of molecules must be combined with imaging techniques that report on the mobility of molecules. - Understanding eukaryotic chemotaxis: a pseudopod-centred view
Insall RH - Nat Rev Mol Cell Biol 11(6):453 (2010)
Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form. This 'signal-centred' approach is widely accepted but is derived mostly from special cases, particularly steep chemoattractant gradients. I propose a 'pseudopod-centred' explanation, whereby most pseudopods form themselves, without needing exogenous signals, and chemoattractants only bias internal pseudopod dynamics. This reinterpretation of recent data suggests that future research should focus on pseudopod mechanics, not signal processing.
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